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We are now "Susans at Antonino Salon" specializing in Human Hair, Human Hair/Synthetic Blend and Synthetic wigs. I am an Oncology Nurse and Breast Cancer Survivor offering products for women undergoing Chemotherapy and Radiation Treatment since 1994. “The Fit of Custom Made. The Value of Custom Tailored.” CALL us at 248.544.4287 for your FREE appointment on Monday and Tuesday from 10 AM to 4 PM. We are located within Antonino Salon, 191 Townsend, Birmingham, MI 48009.
Saturday, September 21, 2019
Tuesday, September 3, 2019
How current hormone treatments can send breast cancer cells into a dormant “sleeper mode”
The study offers new insights into what triggers certain breast cancer cells to become dormant 'sleeper' cells (red) or remain active cancer cells (green).
Luca Magnani et al. Nature Communications 2019
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The looming threat of a relapse is something that hovers over many cancer survivors. Breast cancer in particular is known to enter extremely long dormant periods, and a new study led by researchers from Imperial College London is suggesting the drugs used to initially treat the cancer may be responsible, triggering some cancer cells to enter a sleeper state.
Around 70 percent of breast cancers are classified as oestrogen-receptor positive. This means the cancer utilizes oestrogen to grow, and following an initial surgery hormone drug therapy is usually administered. However, the relapse rate for patients undergoing this kind of hormone therapy is about 30 percent, and the cancer can unexpectedly recur as late as 20 years after initial treatment.
“For a long time scientists have debated whether hormone therapies – which are a very effective treatment and save millions of lives – work by killing breast cancer cells or whether the drugs flip them into a dormant ‘sleeper’ state,” says Luca Mangani, lead author on the new study.
Investigating thousands of breast cancer cells in the lab, the new study discovered current hormone treatments can in fact trigger some cancer cells to enter a dormant phase. Not only that, but the researchers also suspect this dormant phase to be part of the process the cancer cells move through before ultimately becoming resistant to the hormone therapy.
“These sleeper cells seem to be an intermediate stage to the cells becoming resistant to the cancer drugs,” explains Iros Barozzi, co-author on the new study. “The findings also suggest the drugs actually trigger the cancer cells to enter this sleeper state.”
This new study in no way suggests women be hesitant in undergoing hormone therapy to treat breast cancer but instead it directs researchers to new understandings into how cancer cells enter dormant phases and why they reawaken years later. Answering these questions could help prevent long-term breast cancer relapses.
“If we can unlock the secrets of these dormant cells, we may be able to find a way of preventing cancer coming back, either by holding the cells in permanent sleep mode, or be waking them up and killing them,” says Mangani.
The new study was published in the journal Nature Communications.
Source: Imperial College London
Can low gravity kill cancer? Scientists prepare to study cells in space
Next year, scientists will send cancer cells for study aboard the International Space Station
NASA
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We’ve been sending humans to space for more than half a century now, but there is still so much to learn about how a low-gravity environment impacts our physiology. An Australian scientist has been looking into such matters through simulation studies here on Earth, and with early indications that space can kill off the majority of cancer cells without the need for drugs, is now preparing to launch his experiments toward the International Space Station for further investigation.
There are quite a few studies that have been completed or are ongoing at the International Space Station that explore the effects of low-gravity on living organisms and human physiology.
NASA has previously studied cellular changes of mice and mussels on the ISS to gain new insights into the human immune system and looked into how the microgravity environment can lead to vision impairment. The agency’s twin study, meanwhile, comparing the biology of an identical twin who spent almost a year at the ISS with the other who did not, continues to be one of the more intriguing examples.
But the intricacies of how cancer cells behave in the microgravity environment remains largely unexplored. Biomedical engineer Joshua Chou has been conducting experiments in his laboratory at the University of Technology Sydney to advance our understanding of this, using a micro-gravity simulator to observe how cancer cells respond and the potential reasons why.
“Prior to this research, most focus has been on the genetic expression of cancer under microgravity,” Chou explains to New Atlas. “But no one has looked at the mechanisms, and the strategy of how we are approaching this is to identify the sensing receptors in the cancer, in hope of tricking them.”
Chou and his student Anthony Kirollos exposed ovarian, breast, nose and lung cancer cells to the micro-gravity simulator for a 24-hour period, and found that it caused 80 to 90 percent of them to die, as first reported by the ABC. The scientists believe this is because the lack of gravitational force on the cells influences how they communicate with one another and makes them unable to sense their surroundings, something they call mechanical unloading.
“I have to clarify that microgravity does affect other cells, like bone cells, that is why astronauts lose bone,” Chou tells us. “But having said that, the different tissues and organs in the body respond differently, and it’s just that we found bone and cancers are super sensitive to the effects of microgravity.”
Why this mechanical unloading effect hits cancer cells harder than most is one of the questions Chou hopes to shed some light on when he launches his experiment for the ISS next year. In the first Australian research mission to the ISS, the cells will be packed into a device smaller than a tissue box and studied within the micro-gravity environment for a period of one week.
“Twenty-four hours before launch, we will introduce the cells into microfluidic devices, they will go up to the ISS and the experiment will be carried out for seven days, but won’t return until after 28 days at the ISS,” Chou says. “Then of course we will do analysis upon its return. But we also designed technologies to study them while they are alive on the ISS.”
Sending cancer patients to space for treatment certainly seems a fanciful idea, and Chou isn’t looking to change that through his inventive line of investigation. The hope is that the experiments can shed light on the specific receptors and sensors behind the mechanical unloading effect on cancer cells, so scientists can design drugs that mimic the same effects here on Earth.
"I see what we are developing on working in conjunction with existing therapies and not replacing anything,“ Chou says. “What we hope is that it will increase efficiency of current drugs to give the patient an added advantage by disrupting the normal function of the cancer. Because if the cells can't 'function as a team' then it becomes easier to kill them.”
Source: ABC
FOR
“THOSE” TIMES IN OUR LIVES
ALOPECIA. CHEMOTHERAPY.
HAIR LOSS.
Now the expertise of two - Susan’s @ Antonino and Antonino Salon & Spa. We are so excited to take our wig services to a new level. You can explore new dimensions in fashion, color and style for your human hair wig. Whether you are going to that special evening event or just out for lunch around town your wig can be an extension of your inner self. We can create the look you have only dreamed about – from casual to formal. Once you have determined the look and feel we will custom tailor your wig so not only will you look great - you will be comfortable and secure.
You will first meet with Susan, Oncology Nurse and Breast Cancer Survivor, who will gently discuss your specific needs including price range style of wig, timing, wig care instructions including tips on how to keep your wig healthy. Then you will consult with our wonderful cosmetologist to find your perfect wig. We are here to help you during the loss of your hair whether from chemotherapy, alopecia or other. Depending upon your chemotherapy drug and cycle will determine how long you will be experiencing hair loss. That will help you decide what is right for you - Synthetic, Human Hair/Synthetic Blend, Human Hair.
Please call 248-544-4287 for your FREE consultation to explore solutions that are right for you. Susan's @ Antonino is by appointment only on Monday and Tuesday from 10:00 - 4:00. Wigs. Hairpieces. With Antonino Salon for Haircut. Style. Facial, Makeup. Nails. Massage.
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