Cancer
is a disease of genes gone wrong. When certain genes mutate, they make cells
behave in odd ways. The cells divide swiftly, they hide from the immune system
that could kill them and they gain the nourishment they need to develop into
tumors.
Scientists
started identifying these cancer genes in the 1970s and their list slowly grew
over the years. By studying them, scientists came to understand how different
types of cancer develop and in some cases they were even able to develop
gene-targeting drugs. Last May, for example, the Food and Drug Administration approved a drug known as Tarceva to treat
lung cancer in which a gene called EGFR has mutated.
The
National Institutes of Health, hoping to speed up the identification of cancer
genes, started an
ambitious project in 2005 called theCancer Genome Atlas.
They analyzed 500 samples from each of over 20 types of cancer and found a
wealth of new genes. The data have helped scientists discover more of the
tricks cancer cells use to thrive at our expense.
“The
Cancer Genome Atlas has been a spectacular success, there’s no doubt about
that,” said Bruce Stillman, the president of Cold Spring
Harbor Laboratory.
But
now, as the Atlas project is coming to an end, researchers at the Broad
Institute of M.I.T. and Harvard have published a study in the journal Nature
that has scientists debating where cancer research should go next. They
estimated that scientists would need to examine about 100,000 cancer samples
—10 times as many as the $375 million Cancer Genome Atlas has gathered — to
find most of the genes involved in 50 cancer types.
“We now
know what it would take to get a complete catalog,” said Eric S. Lander, the founding director of the
Broad Institute and a co-author of the new study. “And we now know
we’re not close to done. We have a lot left to learn.”
Traditionally,
scientists have identified cancer genes by comparing healthy cells with
cancerous ones. If they find a statistically unusually high number of cells
with mutations in a particular gene, they can then examine it to see if it
really does help drive cancer — or if it is just carrying a harmless mutation.
Dr.
Lander and his colleagues suspected this method could miss some genes. While
some cancer genes affect most cells of a given type of cancer, other genes are
only involved in a fraction of them. (EGFR, the gene treated with Tarceva, is
mutated in only about 10 percent of cases of nonsmall cell lung cancer.) Small
samples of cancer cells might not contain the less common mutations.
The
Broad researchers suspected that they could catch some of these missing genes
by looking at several cancer types at once, because some genes are not limited
to a single type of cancer.
For
their new study, the scientists examined cancer samples from the Cancer Genome
Atlas, as well as cancer samples from the Broad’s own collection. All told,
they analyzed 4,742 samples from 21 types of cancer.
The new
study detected many of the genes that other scientists have previously linked
to those 21 types of cancer. But they also found new genes that had been
overlooked before. All told, they identified 33 genes that they consider strong
candidates for playing a role in cancer — a potential increase of the catalog
of cancer genes of 25 percent.
“This
was eye-opening to me,” said Dr. Lander.
Dr.
Lander and his colleagues began to wonder how many genes could be found if
scientists looked at more cancer samples. Was the cancer catalog almost
finished, or only just begun?
“We
were able to ask for the first time, ‘Are we there yet?'” said Dr. Lander.
They
extrapolated from their own results to gauge how many more samples scientists
would need to look at to find most cancer genes involved in at least 2 percent
of cancers of a given type.
To find
most cancer genes involved in the 50 most common types of cancer, the
researchers estimated that they would have to analyze 100,000 samples. In other
words, the atlas has gotten us a tenth of the way to the finish line.
Dr. Harold Varmus, the director of the
National Cancer Institute, said the study has raised valuable questions. “The
paper provides some models about what we might think about doing next,” he
said. He said the agency is now considering testing Dr. Lander’s hypothesis on
a few types of cancer by gathering more samples.
Dr.
Lander and his colleagues argue for finishing off the cancer gene catalog.
“Completing the genomic analysis of this disease should be a biomedical
imperative,” they wrote in their new paper.
In an
interview, Dr. Lander said knowing most genes involved in cancer would be a
powerful weapon against the disease. “How could we think of beating cancer in
the long term without having the whole catalog?” he said. “It would be crazy
not to have the information.”
But Dr.
Stillman of Cold Spring Harbor Laboratory said completing the atlas has to be
weighed against other needs. “Whether we need to know every cancer gene, I’d
like to see an argument for how that’s going to help the advancement of new
therapy,” he said.
For
many researchers, the question comes down to whether extending the atlas
project would be the best use of existing research funds. “There’s no question
that it would be valuable. The question is whether it’s worth it,” said Dr. Bert Vogelstein, a Howard Hughes Medical
Institute Investigator at Johns Hopkins University.
Some
scientists say it might make more sense to study common cancer genes that have
already been identified, instead of searching for relatively rare genes that
might not turn out to be helpful in fighting cancer.
Also in
question is who would pay for advancing the cancer catalog project. “We still
don’t know how much money we’re going to have this year,” said Dr. Varmus of
the National Cancer Institute’s budget. “We’re not going to set off tomorrow
and do 100,000 complete genomes.”
Dr.
Lander argued that the project could be done for a reasonable cost, and might
also be supported by philanthropic organizations or international partners. In
any case, he said, he welcomed a debate about when science will finish the
cancer gene catalog.
“If
people say, ‘I would rather not know that for five years, or 10 years,’ that’s
a reasonable argument,” said Dr. Lander. “But I would rather know that sooner.”
Correction: February 6,
2014
Because of an editing
error, an earlier version of this article misstated a finding of the new
study. The researchers estimated that scientists would need to examine
about 100,000 cancer samples — not genes — to find most of the genes involved
in 50 cancer types.
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